Serological Markers (Trisomy 21)
Maternal serum collected at 14-17+6 weeks of amenorrhoea can be measured for 2 or 3 markers:
Down’s Syndrome risk assessment is calculated using the following markers:
If risk assessment is ≥ 1/250, amniocentesis and karyotyping is recommended. If AFP is ≥ 2.50 kU/L, an ultrasound examination is also recommended, notably to investigate the possibility of an abdominal wall or neural tube defect.
Assays are carried out using an immunofluorimetric method on Perkin Elmer AutoDelfia machines, and the risk is calculated by Elipse/ LifeCycle software (CE Marking).
Research and Development
Further investigations for foetal and obstetric abnormalities other than trisomy 21, can be performed.
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